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(11)

EP 1 931 374 A2

(12)

(43) Date of publication: 18.06.2008 Bulletin 2008/25 (21) Application number: 06749687.7 (22) Date of filing: 10.04.2006

(51) International Patent Classification (IPC):  A61K 38/29(2006.01) A61K 47/24(2006.01) A61K 47/40(2006.01) A61K 47/18(2006.01) A61K 47/26(2006.01) (86) International application number: PCT/US2006/013377 (87) International publication number: WO 2007/044069 (19.04.2007 Gazette 2007/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (30) Priority: 06.10.2005 US 246450 06.10.2005 US 246406 03.02.2006 US 347551 27.03.2006 US 390940 (71) Applicant: Nastech Pharmaceutical Company Inc. Bothell, WA 98021-8906 (US)	(72) Inventors: COSTANTINO, Henry, R. Woodinville, WA 98072 (US) QUAY, Steven, C. Seattle, WA 98122 (US) TEMPLIN, Michael, V. Bothell, WA 98122 (US) LI, Ching-yuan Bellevue, WA 98006 (US) SILENO, Anthony Brookhaven Hamlet, NY 11719 (US) (74) Representative: Maggs, Michael Norman et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)