(19)

(11)

EP 1 943 277 A2

(12)

(88) Date of publication A3: 10.05.2007 (43) Date of publication: 16.07.2008 Bulletin 2008/29 (21) Application number: 06763512.8 (22) Date of filing: 05.06.2006

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 5/20(2006.01) C07K 14/705(2006.01) G01N 33/68(2006.01) A61K 39/395(2006.01) C12N 15/13(2006.01) A61K 38/17(2006.01) (86) International application number: PCT/EP2006/062908 (87) International publication number: WO 2006/131512 (14.12.2006 Gazette 2006/50)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 07.06.2005 GB 0511590 (71) Applicant: Trigen GmbH 82152 Martinsried (DE)	(72) Inventors: MÜNCH, Götz 82152 Martinsried (DE) BÜLTMANN, Andreas 82152 Martinsried (DE) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)