(19)

(11)

EP 1 943 343 A2

(12)

(88) Date of publication A3: 28.06.2007 (43) Date of publication: 16.07.2008 Bulletin 2008/29 (21) Application number: 06825155.2 (22) Date of filing: 28.09.2006

(51) International Patent Classification (IPC):  C12N 15/52(2006.01) C12N 15/63(2006.01) C07K 14/47(2006.01) (86) International application number: PCT/US2006/037597 (87) International publication number: WO 2007/038564 (05.04.2007 Gazette 2007/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 28.09.2005 US 238096 07.12.2005 US 748315 P (71) Applicant: THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02139 (US)	(72) Inventors: ALPER, Hal, S. Cambridge, MA 02138 (US) STEPHANOPOULOS, Gregory Winchester, MA 01890 (US) (74) Representative: White, Nina Louise  Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)