(19)

(11)

EP 1 943 350 A2

(12)

(88) Date of publication A3: 05.07.2007 (43) Date of publication: 16.07.2008 Bulletin 2008/29 (21) Application number: 06825387.1 (22) Date of filing: 29.09.2006

(51) International Patent Classification (IPC):  C12P 21/04(2006.01) C07K 1/00(2006.01) C07K 17/00(2006.01) A61K 36/14(2006.01) A61K 38/00(2006.01) C07K 14/00(2006.01) A61K 51/00(2006.01) A01N 37/18(2006.01) (86) International application number: PCT/US2006/038584 (87) International publication number: WO 2007/044321 (19.04.2007 Gazette 2007/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 04.10.2005 US 723511 P (71) Applicant: Greenville Hospital System Greenville, SC 29605-4295 (US)	(72) Inventors: WAGNER, Thomas, E. Greer, SC 29650 (US) YU, Xianzhang Mauldin, SC 29602 (US) (74) Representative: Helbing, Jörg  Patentanwälte Von Kreisler-Selting-Werner Postfach 10 22 41 50462 Köln 50462 Köln (DE)