(19)

(11)

EP 1 945 664 A2

(12)

(88) Date of publication A3: 01.11.2007 (43) Date of publication: 23.07.2008 Bulletin 2008/30 (21) Application number: 06801912.4 (22) Date of filing: 21.08.2006

(51) International Patent Classification (IPC):  C07K 16/00(2006.01) (86) International application number: PCT/US2006/032443 (87) International publication number: WO 2007/024735 (01.03.2007 Gazette 2007/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 19.08.2005 US 710026 P (71) Applicant: Charm Sciences Inc. Lawrence, MA 01843-1032 (US)	(72) Inventors: LAW, Say-jong Westwood, MA 02090 (US) SAUL, Steven J. Arlington, MA 02174 (US) CHARM, Stanley, E. Boston, MA 02110 (US) (74) Representative: Webb, Andrew John  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5JJ Gray's Inn London WC1R 5JJ (GB)