| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE
SI SK TR |
| (30) |
Priority: |
18.10.2005 JP 2005303497
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| (43) |
Date of publication of application: |
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23.07.2008 Bulletin 2008/30 |
| (73) |
Proprietor: Otsuka Pharmaceutical Co., Ltd. |
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Tokyo 101-8535 (JP) |
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| (72) |
Inventors: |
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- TOYOBUKU, Hidekazu
Tokushima-shi
Tokushima 771-0182 (JP)
- MIYAO, Hideo
Tokushima-shi
Tokushima 771-0182 (JP)
- SATO, Masako
Tokushima-shi
Tokushima 771-0192 (JP)
- SEKIGUCHI, Kazuo
Otsu-shi
Shiga 520-0106 (JP)
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| (74) |
Representative: HOFFMANN EITLE |
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Patent- und Rechtsanwälte
Arabellastrasse 4 81925 München 81925 München (DE) |
| (56) |
References cited: :
WO-A1-00/27795 WO-A1-2004/004758 US-A- 5 965 542
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WO-A1-99/31132 WO-A2-2004/033620
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vol. 49, no. 1, 2002, pages 285-290, XP002665623, ISSN: 0001-527X
- SONG Y K ET AL: "Free liposomes enhance the transfection activity of DNA/lipid complexes
in vivo by intravenous administration.", BIOCHIMICA ET BIOPHYSICA ACTA 24 JUN 1998
LNKD- PUBMED:9651508, vol. 1372, no. 1, 24 June 1998 (1998-06-24), pages 141-150,
XP002665624, ISSN: 0006-3002
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TODAY vol. 1, no. 5, 1998, pages 206 - 213, XP003012138
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of DDAB-DOPE and DC-Chol-DOPE lipoplexes contributes to explain their different transfection
efficiency' COLLOIDS SURF B BIOINTERFACES vol. 53, no. 2, 01 December 2006, pages
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