(19)

(11)

EP 1 948 605 A2

(12)

(88) Date of publication A3: 23.08.2007 (43) Date of publication: 30.07.2008 Bulletin 2008/31 (21) Application number: 06837763.9 (22) Date of filing: 16.11.2006

(51) International Patent Classification (IPC):  C07D 209/52(2006.01) C07D 401/06(2006.01) C07D 403/06(2006.01) C07D 405/14(2006.01) C07D 413/06(2006.01) A61K 31/403(2006.01) A61K 31/4402(2006.01) A61K 31/4409(2006.01) C07D 401/04(2006.01) C07D 403/04(2006.01) C07D 405/10(2006.01) C07D 409/06(2006.01) C07D 417/04(2006.01) A61K 31/422(2006.01) A61K 31/4406(2006.01) (86) International application number: PCT/US2006/044479 (87) International publication number: WO 2007/061741 (31.05.2007 Gazette 2007/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 17.11.2005 US 737624 P (71) Applicant: Arena Pharmaceuticals, Inc. San Diego, CA 92121-3223 (US)

(72) Inventors: SANTORA, Vincent J. Carlsbad, California 92008 (US) COVEL, Jonathan A. San Diego, California 92129 (US) HAYASHI, Rena San Diego, California 92130 (US) WEBB, Robert R. San Diego, California 92129 (US) REN, Albert S. San Diego, California 92130 (US) CHEN, Weichao G. San Diego, California 92130 (US) DUFFIELD, Jonathan J. San Diego, California 92103 (US) IBARRA, Jason B. Las Vegas, Nevada 89139 (US) PULLEY, Michelle La Jolla, California 92037 (US) SEMPLE, Graeme San Diego, California 92127 (US) WEINHOUSE, Michael I. Escondido, California 92029 (US) (74) Representative: Wytenburg, Wilhelmus Johannes et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)