(19)

(11)

EP 1 948 792 A1

(12)

(43) Date of publication: 30.07.2008 Bulletin 2008/31 (21) Application number: 05824940.0 (22) Date of filing: 28.10.2005

(51) International Patent Classification (IPC):  C12N 7/00(2006.01) C12N 15/86(2006.01) C12N 15/85(2006.01) A61K 48/00(2006.01) (86) International application number: PCT/US2005/038918 (87) International publication number: WO 2007/050074 (03.05.2007 Gazette 2007/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (71) Applicants: Mathis, James Michael Shreveport LA 71104 (US) Debenedetti, Arrigo Shreveport LA 71105 (US) Curiel, David T. Birmingham AL 35294 (US)	(72) Inventors: Mathis, James Michael Shreveport LA 71104 (US) Debenedetti, Arrigo Shreveport LA 71105 (US) Curiel, David T. Birmingham AL 35294 (US) (74) Representative: Samson & Partner  Widenmayerstrasse 5 80538 München 80538 München (DE)