(19)

(11)

EP 1 951 876 A2

(12)

(88) Date of publication A3: 15.11.2007 (43) Date of publication: 06.08.2008 Bulletin 2008/32 (21) Application number: 06821354.5 (22) Date of filing: 07.11.2006

(51) International Patent Classification (IPC):  C12N 15/62(2006.01) (86) International application number: PCT/IB2006/054143 (87) International publication number: WO 2007/052238 (10.05.2007 Gazette 2007/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 07.11.2005 ZA 200508983 (71) Applicant: University of Pretoria Hillcrest, 0002 Pretoria (ZA)	(72) Inventors: HUISMANS, Henk 0002 Pretoria (ZA) MAREE, Francois 0002 Pretoria (ZA) (74) Representative: Tetaz, Franck Claude Edouard et al Cabinet Régimbeau 139, rue Vendôme 69477 Lyon Cedex 06 69477 Lyon Cedex 06 (FR)