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EP 1 954 692 A1

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(43) Date of publication: 13.08.2008 Bulletin 2008/33 (21) Application number: 06838347.0 (22) Date of filing: 22.11.2006

(51) International Patent Classification (IPC):  C07D 403/10(2006.01) A61K 31/41(2006.01) A61P 3/04(2006.01) C07D 413/10(2006.01) A61K 31/4245(2006.01) A61P 25/30(2006.01) (86) International application number: PCT/US2006/045328 (87) International publication number: WO 2007/062193 (31.05.2007 Gazette 2007/22)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 28.11.2005 US 740183 P (71) Applicant: Merck and Co., Inc. Rahway, NJ 07065 (US)

(72) Inventors: BAKER, Robert, K. Rahway, New Jersey 07065-0907 (US) HALE, Jeffrey, J. Rahway, New Jersey 07065-0907 (US) MIAO, Shouwu Rahway, New Jersey 07065-0907 (US) RUPPRECHT, Kathleen, M. Rahway, New Jersey 07065-0907 (US) (74) Representative: Buchan, Gavin MacNicol et al Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon, Hertfordshire EN11 9BU Hoddesdon, Hertfordshire EN11 9BU (GB)