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(11)

EP 1 960 553 A2

(12)

(43) Date of publication: 27.08.2008 Bulletin 2008/35 (21) Application number: 06826023.1 (22) Date of filing: 16.10.2006

(51) International Patent Classification (IPC):  C12Q 1/70(2006.01) C12N 5/08(2006.01) C12N 7/00(2006.01) C12N 15/86(2006.01) (86) International application number: PCT/US2006/040373 (87) International publication number: WO 2007/047581 (26.04.2007 Gazette 2007/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 17.10.2005 US 252458 31.08.2006 US 824265 P (71) Applicant: Academia Sinica Taipei 11529 (TW)	(72) Inventors: YU, John, Cheng-Po La Jolla, CA 92037 (US) YU, Alice, Lin-Tsing La Jolla, CA 92037 (US) LING, Thai-Yen Taipei, 105 (TW) (74) Representative: Crease, Devanand John  Keltie Fleet Place House 2 Fleet Place GB-London EC4M 7ET GB-London EC4M 7ET (GB)