(19)

(11)

EP 1 962 844 A2

(12)

(88) Date of publication A3: 21.02.2008 (43) Date of publication: 03.09.2008 Bulletin 2008/36 (21) Application number: 06848925.1 (22) Date of filing: 20.12.2006

(51) International Patent Classification (IPC):  A61K 31/4439(2006.01) A61K 9/20(2006.01) A61K 9/48(2006.01) A61K 9/28(2006.01) A61K 9/50(2006.01) (86) International application number: PCT/US2006/048961 (87) International publication number: WO 2007/075980 (05.07.2007 Gazette 2007/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 20.12.2005 US 314656 20.12.2005 EP 05257891 20.12.2005 WO PCT/US2005/046296 (71) Applicant: Teva Pharmaceutical Industries Ltd 49131 Petah Tiqva (IL)	(72) Inventors: SILVER, David, Isaac 42490 Netanya (IL) ARI-PARDO, Limor Beit Halevi 42870 (IL) ANTLER, Sivan 71700 Modiin (IL) SHTERMAN, Nava 49214 Petach Tikva (IL) DI CAPUA, Simona 44627 Kfar Saba (IL) (74) Representative: Gallagher, Kirk James et al D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)