(19)

(11)

EP 1 962 863 A2

(12)

(43) Date of publication: 03.09.2008 Bulletin 2008/36 (21) Application number: 06845721.7 (22) Date of filing: 18.12.2006

(51) International Patent Classification (IPC):  A61K 31/675(2006.01) C07D 473/12(2006.01) C07D 473/00(2006.01) (86) International application number: PCT/US2006/048250 (87) International publication number: WO 2007/075572 (05.07.2007 Gazette 2007/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 22.12.2005 US 753636 P 22.12.2005 US 753448 P 22.12.2005 US 753698 P (71) Applicant: Conforma Therapeutics Corporation San Diego, CA 82122 (US)

(72) Inventors: KASIBHATLA, Srinivas R. San Diego, CA 92130 (US) ZHANG, Lin San Diego, CA 92129 (US) BOEHM, Marcus F. San Diego, CA 92104 (US) FAN, Junhua San Diego, CA 92130 (US) HONG, Kevin D. San Diego, CA 92105 (US) BIAMONTE, Marco San Diego, CA 92124 (US) SHI, Jiandong San Diego, CA 92122 (US) (74) Representative: Pohlman, Sandra M. et al df-mp Fünf Höfe Theatinerstrasse 16 80333 München 80333 München (DE)