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(11)

EP 1 963 306 A2

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(88) Date of publication A3: 09.08.2007 (43) Date of publication: 03.09.2008 Bulletin 2008/36 (21) Application number: 06841138.8 (22) Date of filing: 22.12.2006

(51) International Patent Classification (IPC):  C07D 401/12(2006.01) A61P 1/04(2006.01) A61K 31/4439(2006.01) (86) International application number: PCT/EP2006/012477 (87) International publication number: WO 2007/071444 (28.06.2007 Gazette 2007/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 22.12.2005 EP 05028252 (71) Applicant: KRKA, tovarna zdravil, d.d., Novo mesto 8501 Novo mesto (SI)	(72) Inventors: KOTAR-JORDAN, Berta 8311 Kostanjevica na Krki (SI) PISEK, Robert 1000 Ljubljana (SI) ZAJC, Natalija 8340-Crnomelj (SI) VAJS, Anamarija 8000 Novo mesto (SI) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)