(19)
(11) EP 1 966 158 A1

(12)

(43) Date of publication:
10.09.2008 Bulletin 2008/37

(21) Application number: 06824527.3

(22) Date of filing: 18.12.2006
(51) International Patent Classification (IPC): 
C07D 237/28(2006.01)
A61K 31/502(2006.01)
A61P 25/22(2006.01)
A61P 25/28(2006.01)
C07D 403/10(2006.01)
 A61K 31/497(2006.01)
A61K 31/506(2006.01)
A61P 25/24(2006.01)
C07D 401/10(2006.01)
(86) International application number:
PCT/SE2006/001433
(87) International publication number:
WO 2007/073283 (28.06.2007 Gazette 2007/26)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL BA HR MK RS

(30) Priority: 20.12.2005 US 752137 P
28.08.2006 US 823693 P

(71) Applicant: AstraZeneca AB
151 85 Södertälje (SE)

(72) Inventors:
  • CHAPDELAINE, Marc
    Wilmington, DE 19850-5437 (US)
  • OHNMACHT, Cyrus
    Wilmington, DE 19810-3455 (US)
  • BECKER, Christopher
    Wilmington, DE 19850-5437 (US)
  • CHANG, Hui-Fang
    Wilmington, DE 19850-5437 (US)
  • DEMBOFSKY, Bruce
    Wilmington, DE 19850-5437 (US)

   


(54) SUBSTITUTED CINNOLINE DERIVATIVES AS GABAA-RECEPTOR MODULATORS AND METHOD FOR THEIR SYNTHESIS