(19)

(11)

EP 1 966 181 A2

(12)

(88) Date of publication A3: 17.07.2008 (43) Date of publication: 10.09.2008 Bulletin 2008/37 (21) Application number: 06851777.0 (22) Date of filing: 01.12.2006

(51) International Patent Classification (IPC):  C07D 317/66(2006.01) C07C 237/04(2006.01) A61K 31/36(2006.01) C07C 235/24(2006.01) C07C 251/48(2006.01) A61P 31/12(2006.01) (86) International application number: PCT/US2006/045950 (87) International publication number: WO 2008/051244 (02.05.2008 Gazette 2008/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 01.12.2005 US 741772 P (71) Applicant: Wyeth Madison, NJ 07940 (US)

(72) Inventors: BLOOM, Jonathan David Piermont, NY 10968 (US) INSAF, Shabana Springfield, MO 65810 (US) NITTOLI, Thomas Pearl River, NY 10965 (US) SUTHERLAND, Alan Gordon New City, NY 10956 (US) CURRAN, Kevin J. Nyack, NY 10960 (US) WHELESS, Karen Pearl River, NY 10965 (US) (74) Representative: Talbott, Dawn Jacqueline  Wyeth Pharmaceuticals, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)