(19)

(11)

EP 1 966 196 A2

(12)

(88) Date of publication A3: 16.08.2007 (43) Date of publication: 10.09.2008 Bulletin 2008/37 (21) Application number: 06845924.7 (22) Date of filing: 19.12.2006

(51) International Patent Classification (IPC):  C07D 451/10(2006.01) A61P 11/06(2006.01) A61K 31/46(2006.01) (86) International application number: PCT/US2006/048690 (87) International publication number: WO 2007/075838 (05.07.2007 Gazette 2007/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 19.12.2005 US 752672 P 27.12.2005 US 754530 P 23.01.2006 US 761437 P 15.02.2006 US 774051 P 07.03.2006 US 780310 P 10.07.2006 US 830231 P 20.07.2006 US 832189 P 03.08.2006 US 835200 P 03.08.2006 US 835201 P 07.08.2006 US 836037 P 12.10.2006 US 851223 P 18.10.2006 US 852740 P (71) Applicant: Sicor, Inc. Irvine, CA 92618 (US)

(72) Inventors: VOLONTÈ, Roberta I-22069 Rovellasca (co) (IT) DIULGHEROFF, Nicola Torino (IT) SCARPITTA, Francesca I-10015 Ivrea (to) (IT) PONTIROLI, Alessandro S. Maria Della Versa (PV) (IT) CASALONE, Roberto I-13048 Santhia' (vc) (IT) (74) Representative: Russell, Tim et al D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)