(19)

(11)

EP 1 968 646 A2

(12)

(88) Date of publication A3: 20.03.2008 (43) Date of publication: 17.09.2008 Bulletin 2008/38 (21) Application number: 06838966.7 (22) Date of filing: 04.12.2006

(51) International Patent Classification (IPC):  A61K 49/00(2006.01) A61P 27/02(2006.01) A61K 38/43(2006.01) (86) International application number: PCT/US2006/046306 (87) International publication number: WO 2007/065021 (07.06.2007 Gazette 2007/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 02.12.2005 US 741763 P 31.05.2006 US 809480 P 16.10.2006 US 852050 P (71) Applicant: Ista Pharmaceuticals, Inc Irvine, CA 92618 (US)	(72) Inventors: HOCHBERG, Alan M. Harrisburg, PA 17102 (US) PEARSON, Ronald K. Harrisburg, PA 17102 (US) (74) Representative: Popp, Eugen et al MEISSNER, BOLTE & PARTNER Widenmayerstrasse 48 80538 München 80538 München (DE)