(19)
(11) EP 1 971 338 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.09.2011 Bulletin 2011/38

(45) Mention of the grant of the patent:
09.03.2011 Bulletin 2011/10

(21) Application number: 06820566.5

(22) Date of filing: 19.12.2006
(51) International Patent Classification (IPC): 
A61K 31/517(2006.01)
A61P 35/00(2006.01)
A61K 31/519(2006.01)
(86) International application number:
PCT/GB2006/004750
(87) International publication number:
WO 2007/071958 (28.06.2007 Gazette 2007/26)

(54)

COMBINATION OF ZD6474 AND PEMETREXED

KOMBINATION VON ZD6474 UND PEMETREXED

COMBINAISON DE ZD6474 ET DE PEMETREXED


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
Designated Extension States:
HR

(30) Priority: 22.12.2005 GB 0526121
31.05.2006 GB 0610706

(43) Date of publication of application:
24.09.2008 Bulletin 2008/39

(73) Proprietor: AstraZeneca AB
151 85 Södertälje (SE)

(72) Inventors:
  • WEDGE, Stephen, Robert
    Cheshire SK10 4TG (GB)
  • RYAN, Anderson, Joseph
    Cheshire SK10 4TG (GB)


(56) References cited: : 
   
  • HUBER PETER E ET AL: "Trimodal cancer treatment: Beneficial effects of combined antianglogenesis, radiation, and chemotherapy" CANCER RESEARCH, vol. 65, no. 9, May 2005 (2005-05), pages 3643-3655,3633, XP002464232 ISSN: 0008-5472
  • BISCHOF M ET AL: "Triple combination of irradiation, chemotherapy (pemetrexed), and VEGFR inhibition (SU5416) in human endothelial and tumor cells" INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, US, vol. 60, no. 4, 15 November 2004 (2004-11-15), pages 1220-1232, XP004618608 ISSN: 0360-3016
  • GLADE-BENDER J ET AL: "VEGF BLOCKING THERAPY IN THE TREATMENT OF CANCER" EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 3, no. 2, April 2003 (2003-04), pages 263-276, XP009060849 ISSN: 1471-2598
  • SRIDHAR SRIKALA S ET AL: "Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer." LUNG CANCER (AMSTERDAM, NETHERLANDS) DEC 2003, vol. 42 Suppl 1, December 2003 (2003-12), pages S81-S91, XP002464233 ISSN: 0169-5002
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).