(19)

(11)

EP 1 971 356 A2

(12)

(88) Date of publication A3: 29.05.2008 (43) Date of publication: 24.09.2008 Bulletin 2008/39 (21) Application number: 06821674.6 (22) Date of filing: 27.12.2006

(51) International Patent Classification (IPC):  A61K 38/05(2006.01) A61K 38/07(2006.01) A61K 38/10(2006.01) A61K 38/06(2006.01) A61K 38/08(2006.01) A61K 31/198(2006.01) (86) International application number: PCT/IL2006/001494 (87) International publication number: WO 2007/074456 (05.07.2007 Gazette 2007/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 29.12.2005 IL 17289605 (71) Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD. 76100 Rehovot (IL)	(72) Inventors: LAPIDOT, Tsvee 74046 Ness Ziona (IL) RUBINSTEIN, Menachem 76329 Rehovot (IL) SPIEGEL, Asaf 55900 Ganei Tikva (IL) FRIDKIN, Mati 76284 Rehovot (IL) KALINKOVICH, Alexander 76217 Rehovot (IL) SHIVTIEL, Shoham 12387 Moshav Kahal (IL) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Leopoldstrasse 4 80802 München 80802 München (DE)