(19)

(11)

EP 1 973 405 A2

(12)

(88) Date of publication A3: 13.12.2007 (43) Date of publication: 01.10.2008 Bulletin 2008/40 (21) Application number: 07716310.3 (22) Date of filing: 08.01.2007

(51) International Patent Classification (IPC):  A01N 43/00(2006.01) A61K 31/33(2006.01) (86) International application number: PCT/US2007/000183 (87) International publication number: WO 2007/087130 (02.08.2007 Gazette 2007/31)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 12.01.2006 US 758297 P (71) Applicant: Merck & Co., Inc. Rahway, NJ 07065-0907 (US)

(72) Inventors: HEIDEBRECHT, Richard, W., Jr. Rahway, New Jersey 07065-0907 (US) MILLER, Thomas, A. Rahway, New Jersey 07065-0907 (US) WILSON, Kevin, J. Rahway, New Jersey 07065-0907 (US) WITTER, David, J. Rahway, New Jersey 07065-0907 (US) GRIMM, Jonathan Rahway, New Jersey 07065-0907 (US) (74) Representative: Hussain, Deeba et al Merck & Co., Inc. Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)