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(11)

EP 1 973 909 A2

(12)

(88) Date of publication A3: 02.08.2007 (43) Date of publication: 01.10.2008 Bulletin 2008/40 (21) Application number: 06848155.5 (22) Date of filing: 22.12.2006

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) C07D 491/20(2006.01) A61K 31/437(2006.01) A61K 31/4985(2006.01) A61P 11/00(2006.01) C07D 487/04(2006.01) C07D 519/00(2006.01) A61K 31/55(2006.01) A61P 9/00(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2006/049271 (87) International publication number: WO 2007/076127 (05.07.2007 Gazette 2007/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 22.12.2005 US 753023 P (71) Applicant: Biogen Idec MA Inc. Cambridge, MA 02142 (US)

(72) Inventors: LEE, Wen-Cherng Lexington, MA 02421 (US) CHUAQUI, Claudio Somerville, MA 02144 (US) SUN, Lihong Arlington, MA 02474 (US) HOEMANN, Michael Marlborough, MA 01752 (US) NIU, Deqiang Lexington, MA 02421 (US) YAN, Dingxue South Grafton, MA (US) BONAFOUX, Dominique Cambridge, MA 02138 (US) CORNEBISE, Mark Watertown, MA 02472 (US) (74) Representative: Mathys & Squire LLP  120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)