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(11)

EP 1 976 851 A2

(12)

(88) Date of publication A3: 04.10.2007 (43) Date of publication: 08.10.2008 Bulletin 2008/41 (21) Application number: 07718002.4 (22) Date of filing: 17.01.2007

(51) International Patent Classification (IPC):  C07D 407/14(2006.01) A61K 31/506(2006.01) C07D 417/14(2006.01) A61P 25/16(2006.01) (86) International application number: PCT/US2007/060632 (87) International publication number: WO 2007/084914 (26.07.2007 Gazette 2007/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 17.01.2006 US 759692 P (71) Applicants: NEUROCRINE BIOSCIENCES, INC. San Diego, CA 92130 (US) Laboratorios Almirall, S.A. 08022 Barcelona (ES)

(72) Inventors: SLEE, Deborah San Diego, California 92130 (US) ZHANG, Xiaohu San Diego, California 92130 (US) RUETER, Jaimie K. San Diego, California 92129 (US) LIN, Emily San Diego, California 92130 (US) CRESPO CRESPO, Maria Isabel E-08036 Barcelona (ES) CASTRO PALOMINO LARIA, Julio Cesar E-08330 Premia de Mar (ES) (74) Representative: Viering, Jentschura & Partner  Grillparzerstrasse 14 81675 München 81675 München (DE)