(19)

(11)

EP 1 976 881 A2

(12)

(88) Date of publication A3: 06.12.2007 (43) Date of publication: 08.10.2008 Bulletin 2008/41 (21) Application number: 07703766.1 (22) Date of filing: 10.01.2007

(51) International Patent Classification (IPC):  C07K 16/24(2006.01) (86) International application number: PCT/EP2007/050219 (87) International publication number: WO 2007/080174 (19.07.2007 Gazette 2007/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: HR (30) Priority: 11.01.2006 GB 0600488 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)

(72) Inventors: ASHMAN, Claire Stevenage Hertfordshire SG1 2NY (GB) CASSIDY, Martin, John Stevenage Hertfordshire SG1 2NY (GB) CLARKSON, Jane, Elizabeth Stevenage Hertfordshire SG1 2NY (GB) ELLIS, Jonathan, Henry Stevenage Hertfordshire SG1 2NY (GB) WATTAM, Trevor, Anthony, Kenneth Stevenage Hertfordshire SG1 2NY (GB) (74) Representative: Hitchcock, Lucy Rose  GlaxoSmithKline 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)