(19)

(11)

EP 1 981 493 A1

(12)

(43) Date of publication: 22.10.2008 Bulletin 2008/43 (21) Application number: 07845502.9 (22) Date of filing: 13.11.2007

(51) International Patent Classification (IPC):  A61K 31/357(2006.01) A61P 43/00(2006.01) A61K 45/06(2006.01) (86) International application number: PCT/CA2007/002032 (87) International publication number: WO 2008/058383 (22.05.2008 Gazette 2008/21)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 13.11.2006 US 858349 P 29.08.2007 US 935753 P (71) Applicants: Chronogen Inc. Montréal, Quebec H1W 4A4 (CA) Sosei Co. Ltd. Tokyo 102-0082 (JP)	(72) Inventors: HEKIMI, Siegfried Montréal, Québec H4P 1E5 (CA) HIHI, Abdelmadjid K. Montréal, Québec H4A 3L5 (CA) BRANICKY, Robyn S. Thornhill, Ontario L3T 4J8 (CA) JIA, Xihua Beijing 100071 (CN) (74) Representative: Thomas, Dean et al Cabinet Ores 36 Rue de St Pétersbourg 75008 Paris 75008 Paris (FR)