(19)

(11)

EP 1 981 974 A2

(12)

(88) Date of publication A3: 28.02.2008 (43) Date of publication: 22.10.2008 Bulletin 2008/43 (21) Application number: 07733881.2 (22) Date of filing: 08.02.2007

(51) International Patent Classification (IPC):  C12N 9/24(2006.01) C07K 7/08(2006.01) A61K 38/10(2006.01) A61P 25/00(2006.01) C07K 7/06(2006.01) A61K 38/08(2006.01) A61K 38/47(2006.01) (86) International application number: PCT/IB2007/000301 (87) International publication number: WO 2007/091159 (16.08.2007 Gazette 2007/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 08.02.2006 EP 06290221 (71) Applicant: Diatos 75014 Paris (FR)	(72) Inventor: ARRANZ, Valérie F-77122 Monthyon (FR) (74) Representative: Breese, Pierre  BREDEMA 38, avenue de l'Opéra 75002 Paris 75002 Paris (FR)