(19)

(11)

EP 1 984 004 A2

(12)

(88) Date of publication A3: 10.01.2008 (43) Date of publication: 29.10.2008 Bulletin 2008/44 (21) Application number: 07718218.6 (22) Date of filing: 17.01.2007

(51) International Patent Classification (IPC):  A61K 31/715(2006.01) (86) International application number: PCT/US2007/001427 (87) International publication number: WO 2007/084661 (26.07.2007 Gazette 2007/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 17.01.2006 US 334763 (71) Applicants: Sloan-Kettering Institute For Cancer Research New York, New York 10021 (US) Biotec Pharmacon ASA 9008 Tromsö (NO)	(72) Inventor: ENGSTAD, Rolf Einar N-9018 Tromsø (NO) (74) Representative: Gardner, Rebecca Katherine  Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)