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EP 1 984 332 A2

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(88) Date of publication A3: 17.01.2008 (43) Date of publication: 29.10.2008 Bulletin 2008/44 (21) Application number: 07718004.0 (22) Date of filing: 16.01.2007

(51) International Patent Classification (IPC):  C07D 209/30(2006.01) C07D 401/04(2006.01) C07D 403/12(2006.01) C07D 413/12(2006.01) C07D 417/12(2006.01) A61K 31/405(2006.01) C07D 209/42(2006.01) C07D 401/14(2006.01) C07D 403/14(2006.01) C07D 417/10(2006.01) C07D 417/14(2006.01) A61P 31/12(2006.01) (86) International application number: PCT/US2007/000923 (87) International publication number: WO 2007/084413 (26.07.2007 Gazette 2007/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 13.01.2006 US 758527 P 13.01.2006 US 331180 13.01.2007 US 653436 (71) Applicant: PTC Therapeutics, Inc. South Plainfield, NJ 07080 (US)

(72) Inventors: KARP, Gary Mitchell Princeton Junction, NJ 08550 (US) AREFOLOV, Alexander Hon, MI 02459 (US) REN, Hongyu Dayton, New Jersey 08810 (US) TURPOFF, Anthony Allan Edison, NJ 08817 (US) WILDE, Richard Gerald Sommerville, NJ 08876 (US) TAKASUGI, James Jan Trenton, NJ 08648 (US) HWANG, Peter Seongwoo Edison, NJ 08817 (US) CHEN, Guangming Bridgewater,New Jersey 08807 (US) CAMPBELL, Jeffrey, Allen, c/o S*Bio Pte Ltd Singapore 117528 (SG) LI, Chunshi East Brunswick, NJ 08816 (US) PAGET, Steven Hillsborough, New Jersey 08844 (US) ZHANG, Nanjing Princeton, New Jersey 08540 (US) ZHANG, Xiaoyan Belle Mead, NJ 08502 (US) ZHU, Jin Raritan, NJ 08869 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)