(19)
(11) EP 1 984 517 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
10.10.2012 Bulletin 2012/41

(45) Mention of the grant of the patent:
29.08.2012 Bulletin 2012/35

(21) Application number: 07717002.5

(22) Date of filing: 23.01.2007
(51) International Patent Classification (IPC): 
C12P 21/00(2006.01)
(86) International application number:
PCT/US2007/002007
(87) International publication number:
WO 2007/087384 (02.08.2007 Gazette 2007/31)

(54)

METHODS FOR MODULATING MANNOSE CONTENT OF RECOMBINANT PROTEINS

VERFAHREN ZUR MODULIERUNG DES MANNOSEGEHALTS REKOMBINANTER PROTEINE

PROCÉDÉS DE MODULATION DE LA TENEUR EN MANNOSE DE PROTÉINES DE RECOMBINAISON


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 23.01.2006 US 761477 P
22.12.2006 US 644345

(43) Date of publication of application:
29.10.2008 Bulletin 2008/44

(73) Proprietor: Amgen Inc.
Thousand Oaks, CA 91320 (US)

(72) Inventors:
  • WU, Jian
    Lynnwood, Washington 98036 (US)
  • LE, Nicole
    Camarillo, California 93012 (US)
  • DE LA CRUZ, Michael
    Camarillo, California 93012 (US)
  • FLYNN, Gregory
    Thousand Oaks, California 91320 (US)

(74) Representative: Grund, Martin 
Grund Intellectual Property Group Nikolaistrasse 15
80802 München
80802 München (DE)


(56) References cited: : 
WO-A-02/00879
WO-A2-2004/076620
WO-A-2005/044303
   
  • LI HUIJUAN ET AL: "Optimization of humanized IgGs in glycoengineered Pichia pastoris" NATURE BIOTECHNOLOGY, vol. 24, no. 2, February 2006 (2006-02), pages 210-215, XP002446623 ISSN: 1087-0156
  • ZHU LEI ET AL: "Production of human monoclonal antibody in eggs of chimeric chickens" NATURE BIOTECHNOLOGY, vol. 23, no. 9, September 2005 (2005-09), pages 1159-1169, XP002446624 ISSN: 1087-0156
  • RUDD PAULINE M ET AL: "Rapid, sensitive sequencing of oligosaccharides from glycoproteins" CURRENT OPINION IN BIOTECHNOLOGY, vol. 8, no. 4, 1997, pages 488-497, XP002446625 ISSN: 0958-1669
  • JEFF CHAPMAN AND JOHN HOBBS: "Putting Capillary Electrophoresis to Work" REPRINT FROM JOURNAL LC-GC, [Online] vol. 17, no. 3, 1999, pages 86-99, XP002446626 Retrieved from the Internet: URL:http://www.beckman.com/literature/Bior esearch/LCGCAR8571A.pdf> [retrieved on 2007-08-13]
  • MONICA THOMAS J ET AL: "Characterization of the glycosylation of a human IgM produced by a human-mouse hybridoma" GLYCOBIOLOGY, IRL PRESS,, GB, vol. 5, no. 2, 1995, pages 175-185, XP009088069 ISSN: 0959-6658
  • JENKINS N ET AL: "Getting the glycosylation right: implications for the biotechnology dustry" NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 14, no. 8, August 1996 (1996-08), pages 975-981, XP002133654 ISSN: 1087-0156
  • GOOCHEE C F ET AL: "Bioprocess factors affecting glycoprotein oligosaccharide structure" DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION; CONTINUOUS CELL LINES: AN INTERNATIONAL WORKSHOP ON CURRENT ISSUES S. KARGER AG, P.O. BOX, ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND; S. KARGER AG, NEW YORK, NEW YORK, USA SERIES : DEVELOPMENTS IN B, 1992, pages 95-104, XP009088065 & MEETING; BETHESDA, MARYLAND, USA; MARCH 20-22, 1991 ISSN: 3-8055-5618-7
  • ANDERSEN D C UND GOOCHEE C F: "The effect of cell-culture conditions on the oligosaccharide structures of secreted glycoproteins" CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 5, 1994, pages 546-549, XP002085767 ISSN: 0958-1669
  • RYU J S ET AL: "Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant chinese hamster ovary cell cultures differs among cell lines.", BIOTECHNOLOGY AND BIOENGINEERING 20 OCT 2000 LNKD- PUBMED:10972928, vol. 70, no. 2, 20 October 2000 (2000-10-20), pages 167-175, ISSN: 0006-3592
   
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