(19)

(11)

EP 1 986 684 A2

(12)

(88) Date of publication A3: 17.04.2008 (43) Date of publication: 05.11.2008 Bulletin 2008/45 (21) Application number: 07750859.6 (22) Date of filing: 15.02.2007

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) C12P 21/08(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2007/004051 (87) International publication number: WO 2007/095338 (23.08.2007 Gazette 2007/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 15.02.2006 US 773994 P (71) Applicant: ImClone Systems Incorporated New York, NY 10014 (US)	(72) Inventor: ZHU, Zhenping Oakland, NJ 07436 (US) (74) Representative: Banford, Paul Clifford  Marks & Clerk Sussex House 83-85 Mosley Street Manchester M2 3LG Manchester M2 3LG (GB)