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(11)

EP 1 986 685 A2

(12)

(88) Date of publication A3: 02.05.2008 (43) Date of publication: 05.11.2008 Bulletin 2008/45 (21) Application number: 07762672.9 (22) Date of filing: 31.01.2007

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) C08G 69/26(2006.01) (86) International application number: PCT/US2007/002704 (87) International publication number: WO 2007/089870 (09.08.2007 Gazette 2007/32)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 31.01.2006 US 345021 31.01.2006 WO PCT/US2006/003412 31.01.2006 WO PCT/US2006/000357 31.01.2006 US 344689 01.02.2006 US 345815 05.09.2006 US 842423 P 10.11.2006 US 858173 P 07.12.2006 US 636230 (71) Applicant: Medivas, LLC San Diego, CA 92121 (US)

(72) Inventors: TURNELL, William Del Mar, CA 92014 (US) DEFIFE, Kristin San Diego, CA 92120 (US) VITIELLO, Maria, A. La Jolla, CA 92037 (US) (74) Representative: Cornish, Kristina Victoria Joy et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)