(19)

(11)

EP 1 987 146 A1

(12)

(43) Date of publication: 05.11.2008 Bulletin 2008/45 (21) Application number: 07749508.3 (22) Date of filing: 29.01.2007

(51) International Patent Classification (IPC):  C12N 15/29(2006.01) C12N 15/10(2006.01) C12N 15/09(2006.01) (86) International application number: PCT/US2007/002487 (87) International publication number: WO 2007/097884 (30.08.2007 Gazette 2007/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 27.01.2006 US 762818 P (71) Applicant: Gentris Corporation Morrisville NC 27560 (US)	(72) Inventors: MURPHY, Michael, P. Raleigh, NC 27606 (US) CLARK, L., Scott. Cary, NC 27511 (US) NAHKLE, Pamela, J. Raleigh, NC 27613 (US) BUTZ, Kenneth, G. Chapel Hill, NC 27516 (US) (74) Representative: Wainwright, Jane Helen  Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)