| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
| (30) |
Priority: |
19.12.2002 US 435079 P
24.04.2003 US 465435 P
|
| (43) |
Date of publication of application: |
|
05.11.2008 Bulletin 2008/45 |
| (60) |
Divisional application: |
|
10180989.5 / 2325651 |
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
03813782.4 / 1587821 |
| (73) |
Proprietor: The Scripps Research Institute |
|
La Jolla, CA 92037 (US) |
|
| (72) |
Inventors: |
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- Kelly, Jeffery W.
La Jolla, CA 92037 (US)
- SEKIJIMA, Yoshiki
Matsumoto 390-0877 (JP)
|
| (74) |
Representative: Weber, Martin et al |
|
Jones Day
Prinzregentenstraße 11
80538 München
80538 München (DE) |
| (56) |
References cited: :
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- PETERSON S A ET AL: "Inhibiting Transhyretin Conformational Changes That Lead To Amyloid
Fibril Formation" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL
ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 95, 1 October 1998 (1998-10-01), pages 12956-12960,
XP002988070 ISSN: 0027-8424
- MIROY G J ET AL: "INHIBITING TRANSTHYRETIN AMYLOID FIBRIL FORMATION VIA PROTEIN STABILIZATION"
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE,
WASHINGTON, DC, vol. 93, no. 26, 1 December 1996 (1996-12-01), pages 15051-15056,
XP002070247 ISSN: 0027-8424
- KELLEY J W: "The Environment Dependency of Protein Folding Best Explains Prion and
Amyloid Diseases" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL
ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 95, 1 February 1998 (1998-02-01), pages 930-932,
XP002988069 ISSN: 0027-8424
- LASHUEL H A ET AL: "New Class Of Inhibitors Of Amyloid-beta Fibril Formation" JOURNAL
OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,;
US, vol. 277, no. 45, 1 November 2002 (2002-11-01), pages 42881-42890, XP002988068
ISSN: 0021-9258
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