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(11)

EP 1 991 528 A2

(12)

(88) Date of publication A3: 07.02.2008 (43) Date of publication: 19.11.2008 Bulletin 2008/47 (21) Application number: 07722757.7 (22) Date of filing: 17.01.2007

(51) International Patent Classification (IPC):  C07D 211/60(2006.01) C07D 213/40(2006.01) C07D 231/40(2006.01) C07D 233/88(2006.01) C07D 295/14(2006.01) C07D 401/04(2006.01) C07D 409/04(2006.01) C07D 213/38(2006.01) C07D 231/12(2006.01) C07D 233/54(2006.01) C07D 295/12(2006.01) C07D 295/18(2006.01) C07D 403/12(2006.01) C07C 231/00(2006.01) (86) International application number: PCT/EP2007/000382 (87) International publication number: WO 2007/098826 (07.09.2007 Gazette 2007/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 18.01.2006 US 743141 P 18.01.2006 US 743144 P (71) Applicants: Siena Biotech S.p.A. 53100 Siena (IT) Wyeth Pharmaceuticals Princeton, NJ 08543-8000 (US)

(72) Inventors: BOTHMANN, Hendrick 53100 Siena (IT) RONCARATI, Renza 53100 Siena (IT) BETTINETTI, Laura 53100 Siena (IT) QUINN, Joanna 53100 Siena (IT) VARRONE, Maurizio 53100 Siena (IT) VALACCHI, Michela 53100 Siena (IT) NENCINI, Arianna 53100 Siena (IT) MICCO, Iolanda 53100 Siena (IT) GHIRON, Chiara 53100 Siena (IT) HAYDAR, Simon Princeton, NJ 08543-8000 (US) (74) Representative: Banfi, Paolo  Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 20129 Milano 20129 Milano (IT)