(19)

(11)

EP 1 996 619 A2

(12)

(43) Date of publication: 03.12.2008 Bulletin 2008/49 (21) Application number: 07750916.4 (22) Date of filing: 14.02.2007

(51) International Patent Classification (IPC):  C07K 14/715(2006.01) (86) International application number: PCT/US2007/004114 (87) International publication number: WO 2007/095353 (23.08.2007 Gazette 2007/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 14.02.2006 US 772991 P (71) Applicant: Geisinger Clinic Danville PA 17822 (US)	(72) Inventors: LEUNG, TinChung Danville, Pennsylvania 17821 (US) ROBISHAW, Janet D. Catawissa, Pennsylvania 17820 (US) (74) Representative: Dörries, Hans Ulrich  df-mp Fünf Höfe Theatinerstrasse 16 80333 München 80333 München (DE)