(19)
(11) EP 1 996 643 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
07.04.2010 Bulletin 2010/14

(45) Mention of the grant of the patent:
24.02.2010 Bulletin 2010/08

(21) Application number: 07711258.9

(22) Date of filing: 07.03.2007
(51) International Patent Classification (IPC): 
C08G 63/664(2006.01)
C08J 9/00(2006.01)
A61L 27/18(2006.01)
A61L 27/56(2006.01)
C08G 81/00(2006.01)
C08J 9/28(2006.01)
A61L 15/26(2006.01)
(86) International application number:
PCT/DK2007/000115
(87) International publication number:
WO 2007/101443 (13.09.2007 Gazette 2007/37)

(54)

DEGRADABLE HYDROPHILIC BLOCK COPOLYMERS WITH IMPROVED BIOCOMPATIBILITY FOR SOFT TISSUE REGENERATION

ABBAUBARE COPOLYMERE MIT EINEM HYDROPHILEN BLOCK MIT VERBESSERTER BIOKOMPATIBILITÄT FÜR DIE WEICHGEWEBEREGENERATION

COPOLYMÈRES A BLOC HYDROPHILES DÉGRADABLES PRESENTANT UNE BIOCOMPATIBILITÉ AMÉLIORÉE POUR LA RÉGÉNÉRATION DES TISSUS MOUS


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30) Priority: 09.03.2006 DK 200600337
01.09.2006 DK 200601131
26.10.2006 WO PCT/EP2006/067837

(43) Date of publication of application:
03.12.2008 Bulletin 2008/49

(73) Proprietor: Coloplast A/S
3050 Humlebæk (DK)

(72) Inventors:
  • VANGE, Jakob
    DK-3000 Helsingoer (DK)
  • SCHWACH-ABDELLAOUI, Khadija
    DK-2880 Bagsvaerd (DK)
  • EVERLAND, Hanne
    DK-2880 Bagsværd (DK)
  • NIELSEN, Peter, Sylvest
    DK-3500 Værløse (DK)
  • NIELSEN, Brian
    DK-3330 Gørløse (DK)
  • JESPERSEN, Lene, Karin
    DK-3480 Fredensborg (DK)
  • NIELSEN, Lene, Feldskov
    DK-1054 Copenhagen K (DK)

(74) Representative: Inspicos A/S 
Kogle Allé 2 P.O. Box 45
2970 Hørsholm
2970 Hørsholm (DK)


(56) References cited: : 
EP-A1- 1 234 587
US-A- 4 716 203
US-A- 5 621 050
US-B1- 6 562 374
EP-A2- 1 621 216
US-A- 5 102 983
US-A1- 2002 018 797
   
  • BELETSI A ET AL: "Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers" INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 298, no. 1, 14 July 2005 (2005-07-14), pages 233-241, XP004943756 ISSN: 0378-5173
  • WITT C ET AL: "The degradation, swelling and erosion properties of biodegradable implants prepared by extrusion or compression moulding of poly(lactide-co-glycolide) and ABA triblock copolymers" BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 21, no. 9, May 2000 (2000-05), pages 931-938, XP004202459 ISSN: 0142-9612
  • GREF R ET AL: "BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES" SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 263, 18 March 1994 (1994-03-18), pages 1600-1603, XP002013571 ISSN: 0036-8075
  • RONNEBERGER B., KAO W.J., ANDERSON J.M., KISSEL T.: "In vivo biocompatibility study of ABA triblock copolymers consisting of poly(lactic-co-glycolic acid) A blocks attache to central pol(oxyethylene) B Blocks" JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 30, 1996, pages 31-40, XP002405091
  • MORLOCK M.,KISSEL T., LI Y.X., KOLL H., WINTER G.: "Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties" JOURNAL OF CONTROLLED RELEASE, vol. 56, 1998, pages 105-115, XP002405092
  • KIM K ET AL: "Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds" JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 98, no. 1, 23 July 2004 (2004-07-23), pages 47-56, XP004520545 ISSN: 0168-3659
  • ZANGE R ET AL: "Biocompatibility testing of ABA triblock copolymers consisting of poly(L-lactic-co-glycolic acid) A blocks attached to a central poly(ethylene oxide) B block under in vitro conditions using different L929 mouse fibroblasts cell culture models" JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 56, no. 1-3, 4 December 1998 (1998-12-04), pages 249-258, XP004153938 ISSN: 0168-3659
  • SHIN K C ET AL: "A facile preparation of highly interconnected macroporous PLGA scaffolds by liquid-liquid phase separation II" POLYMER, ELSEVIER SCIENCE PUBLISHERS B.V, GB, vol. 46, no. 11, 11 May 2005 (2005-05-11), pages 3801-3808, XP004904279 ISSN: 0032-3861
  • LEE S Y ET AL: "In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction" BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 24, no. 27, December 2003 (2003-12), pages 5049-5059, XP004464376 ISSN: 0142-9612
   
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