(19)

(11)

EP 1 996 918 A1

(12)

(43) Date of publication: 03.12.2008 Bulletin 2008/49 (21) Application number: 07731974.7 (22) Date of filing: 27.02.2007

(51) International Patent Classification (IPC):  G01N 21/31(2006.01) G01M 3/38(2006.01) G01N 21/35(2006.01) (86) International application number: PCT/GB2007/000697 (87) International publication number: WO 2007/107695 (27.09.2007 Gazette 2007/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 20.03.2006 GB 0605486 (71) Applicant: ISIS INNOVATION LIMITED Summertown, Oxford OX2 7BZ (GB)	(72) Inventors: DOBSON Peter James OX2 7ER (GB) PINCHER Leonard NR16 1LX (GB) PADBURY Christopher John CB2 4QW (GB) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds Yorkshire LS2 8DD Leeds Yorkshire LS2 8DD (GB)