| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO
SE SI SK TR |
|
Designated Extension States: |
|
AL BA HR MK RS |
| (30) |
Priority: |
06.03.2006 US 779806 P
|
| (43) |
Date of publication of application: |
|
10.12.2008 Bulletin 2008/50 |
| (60) |
Divisional application: |
|
13159009.3 / 2639242 |
| (73) |
Proprietor: MedImmune, LLC |
|
Gaithersburg, MD 20878 (US) |
|
| (72) |
Inventors: |
|
- HILBERT, David
Bethesda, MD 20817 (US)
- JONES, Tarran
Hertforshire WD7 8AG (GB)
- WILLIAMS, David, G.
Surrey KT18 7LY (GB)
|
| (74) |
Representative: Gibbs, Richard |
|
Marks & Clerk LLP
Aurora
120 Bothwell Street
Glasgow G2 7JS
Glasgow G2 7JS (GB) |
| (56) |
References cited: :
WO-A1-94/27638
WO-A2-2007/103469
US-A1- 2004 001 828
US-A1- 2007 264 260
|
WO-A2-03/093320
US-A1- 2003 202 975
US-A1- 2005 118 182
|
|
| |
|
|
- TUSCANO JOSEPH M ET AL: "Anti-CD22 ligand-blocking antibody HB22.7 has independent
lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma
xenografts." BLOOD 1 MAY 2003, vol. 101, no. 9, 1 May 2003 (2003-05-01), pages 3641-3647,
XP002540281 ISSN: 0006-4971
- O'DONNELL ROBERT T ET AL: "Treatment of non-Hodgkin's lymphoma xenografts with the
HB22.7 anti-CD22 monoclonal antibody and phosphatase inhibitors improves efficacy."
CANCER IMMUNOLOGY, IMMUNOTHERAPY : CII OCT 2009, vol. 58, no. 10, October 2009 (2009-10),
pages 1715-1722, XP002540282 ISSN: 1432-0851
- ENGEL P ET AL: "THE SAME EPITOPE ON CD22 OF LYMPHOCYTES MEDIATES THE ADHESION OF ERYTHROCYTES,
T AND B LYMPHOCYTES, NEUTROPHILS, AND MONOCYTES" JOURNAL OF IMMUNOLOGY, AMERICAN ASSOCIATION
OF IMMUNOLOGISTS, US, vol. 150, no. 11, 1 June 1993 (1993-06-01) , pages 4719-4732,
XP000999233 ISSN: 0022-1767
- TUSCANO ET AL.: 'Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal
properties and augments the efficaci of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts'
BLOOD vol. 101, no. 9, May 2003, pages 3641 - 3647, XP002540281
- TUSCANO ET AL.: 'Engagement of the adhesion receptor CD22 triggers a potent stimulatory
signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation'
BLOOD vol. 87, no. 11, 1996, pages 4723 - 4730, XP008130974
- ENGEL ET AL.: 'The same epitope on CD22 of B lymphocytes medaites the adhesion of
erythrocytes, T and B lymphocytes, neutrophils, and monocytes' J. IMMUNOL. vol. 150,
no. 11, 1993, pages 4719 - 4732, XP000999233
|
|
