(19)

(11)

EP 2 002 016 A2

(12)

(88) Date of publication A3: 13.03.2008 (43) Date of publication: 17.12.2008 Bulletin 2008/51 (21) Application number: 07732383.0 (22) Date of filing: 12.04.2007

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/GB2007/001340 (87) International publication number: WO 2007/129000 (15.11.2007 Gazette 2007/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 12.04.2006 US 791754 P (71) Applicant: Medical Research Council 20 Park Crescent London W1B 1AL (GB)	(72) Inventors: THANGAVELU, MADAN Cambridge CB2 2QH (GB) DEAR, Paul Cambridge CB2 2QH (GB) RABBITTS, Terence H. Cambridge CB2 2QH (GB) DASER, Angelica Cambridge CB2 2QH (GB) BANKIER, Alan Sawston, Cambridge CB2 4DE (GB) KONFORTOV, Bernard Swavesey, Cambridge CB24 4QN (GB) (74) Representative: Holliday, Louise Caroline  D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)