(19)

(11)

EP 2 004 210 A2

(12)

(88) Date of publication A3: 21.12.2007 (43) Date of publication: 24.12.2008 Bulletin 2008/52 (21) Application number: 07734153.5 (22) Date of filing: 30.03.2007

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) C07K 14/515(2006.01) C07K 14/47(2006.01) (86) International application number: PCT/IB2007/000831 (87) International publication number: WO 2007/116278 (18.10.2007 Gazette 2007/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 31.03.2006 IT MI20060625 (71) Applicant: Istituto nazionale per la ricerca sul cancro 16132 Genova (IT)	(72) Inventors: BRIGATI, Claudio I-16132 Genova (IT) DELL'EVA, Raffaella I-16132 Genova (IT) NIEDDU, Erika I-16132 Genova (IT) BENELLI, Roberto I-16132 Genova (IT) NOONAN, Douglas, M. I-16132 Genova (IT) ALBINI, Adriana I-16132 Genova (IT) (74) Representative: Banfi, Paolo  Bianchetti Bracco Minoja S.r.l. Via Plinio, 63 20129 Milano 20129 Milano (IT)