(19)

(11)

EP 2 004 591 A1

(12)

(43) Date of publication: 24.12.2008 Bulletin 2008/52 (21) Application number: 07873404.3 (22) Date of filing: 12.03.2007

(51) International Patent Classification (IPC):  C07C 211/00(2006.01) A61K 31/435(2006.01) C07D 211/70(2006.01) A61K 31/135(2006.01) (86) International application number: PCT/US2007/006170 (87) International publication number: WO 2008/127223 (23.10.2008 Gazette 2008/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 10.03.2006 US 781245 P (71) Applicant: The Research Foundation Of State University Of New York Amherst, NY 14228-2567 (US)	(72) Inventors: DAVIES, Huw M.L. E. Amherst, NY 14051 (US) GREGG, Timothy Williamsville, NY 14221 (US) (74) Representative: Pidgeon, Robert John  Appleyard Lees 15 Clare Road Halifax West Yorkshire HX1 2HY Halifax West Yorkshire HX1 2HY (GB)