(19)

(11)

EP 2 004 802 A1

(12)

(43) Date of publication: 24.12.2008 Bulletin 2008/52 (21) Application number: 06721540.0 (22) Date of filing: 20.03.2006

(51) International Patent Classification (IPC):  C12N 1/20(2006.01) A61K 39/112(2006.01) A61K 39/108(2006.01) A61P 31/04(2006.01) (86) International application number: PCT/BE2006/000019 (87) International publication number: WO 2007/106956 (27.09.2007 Gazette 2007/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK (71) Applicant: VRIJE UNIVERSITEIT BRUSSEL 1050 Brussel (BE)	(72) Inventors: DE GREVE, Henri, Marcel, Jozef B-1060 Sint-gillis (BE) ADRIAENSEN, Connie Theresia B-9000 Ghent (BE) HERNALSTEENS, Jean-pierre, Ernest, Clément B-1150 Sint-Pieters-Woluwe (BE) (74) Representative: pronovem  Office Van Malderen Avenue Josse Goffin 158 1082 Bruxelles 1082 Bruxelles (BE)