(19)

(11)

EP 2 007 428 A2

(12)

(88) Date of publication A3: 03.01.2008 (43) Date of publication: 31.12.2008 Bulletin 2009/01 (21) Application number: 07749114.0 (22) Date of filing: 22.01.2007

(51) International Patent Classification (IPC):  A61K 45/00(2006.01) A61K 39/395(2006.01) G01N 33/50(2006.01) A61K 38/17(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2007/001794 (87) International publication number: WO 2007/126455 (08.11.2007 Gazette 2007/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 05.04.2006 US 789645 P 12.12.2006 WO PCT/US2006/006194 (71) Applicant: Genentech, Inc. South San Francisco CA 94080-4990 (US)	(72) Inventors: DE SAUVAGE, Frederic, J. Foster City, California 94404 (US) TIAN, Hua San Francisco, California 94115 (US) (74) Representative: Walton, Seán Malcolm et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)