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EP 2 007 787 A2

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(88) Date of publication A3: 18.09.2008 (43) Date of publication: 31.12.2008 Bulletin 2009/01 (21) Application number: 07781534.8 (22) Date of filing: 09.04.2007

(51) International Patent Classification (IPC):  C07K 5/06(2006.01) C07K 5/10(2006.01) A61P 31/14(2006.01) C07K 5/08(2006.01) A61K 38/00(2006.01) (86) International application number: PCT/US2007/066203 (87) International publication number: WO 2007/121124 (25.10.2007 Gazette 2007/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 11.04.2006 US 791611 P (71) Applicants: NOVARTIS AG 4056 Basel (CH) Novartis Pharma GmbH 1230 Vienna (AT) AT

(72) Inventors: BRANDL, Trixi 4056 Basel (CH) BRITT, Shawn D. Andover, Massachusetts 01810 (US) COTTENS, Sylvain 4108 Witterswil (CH) EHRHARDT, Claus 79541 Lörrach (DE) FU, Jiping Arlington, Massachusetts 02474 (US) KARUR, Subramanian Medford, Massachusetts 02155 (US) LI, Hongju Edison, New Jersey 08820 (US) LU, Peichao Malden, Massachusetts 02148 (US) PARKER, David Thomas Lexington, Massachusetts 02420 (US) PATANE, Michael Reading, Massachusetts 01867 (US) RADETICH, Branko Boston, Massachusetts 02116 (US) RAMAN, Prakash Acton, Massachusetts 01720 (US) RANDL, Stefan Andreas 4057 Basel (CH) RIGOLLIER, Pascal 68100 Mulhouse (FR) SEEPERSAUD, Mohindra Belmont, Massachusetts 02478 (US) SIMIC, Oliver 4053 Basel (CH) TICHKULE, Ritesh Bhanudasji Cambridge, Massachusetts 02141 (US) ZHU, Yanyi Acton, Massachusetts 01720 (US) (74) Representative: Vögeli-Lange, Regina  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)