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EP 2 008 210 A1

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(43) Date of publication: 31.12.2008 Bulletin 2009/01 (21) Application number: 06727316.9 (22) Date of filing: 15.03.2006

(51) International Patent Classification (IPC):  G06F 19/00(2006.01) G01N 33/573(2006.01) C07D 239/02(2006.01) C07D 473/00(2006.01) C07D 239/10(2006.01) C07D 475/00(2006.01) C07D 487/14(2006.01) G01N 33/68(2006.01) C12Q 1/48(2006.01) C07D 239/04(2006.01) C07D 235/04(2006.01) C07D 241/40(2006.01) C07D 487/02(2006.01) (86) International application number: PCT/IB2006/000565 (87) International publication number: WO 2007/105023 (20.09.2007 Gazette 2007/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK YU (71) Applicants: CSIR 0001 Pretoria (ZA) Kenyon, Colin Peter Olivedale Ext 1 2188 Randburg (ZA) Oldfield, Lyndon Carey Birch Acres Ext 6 1618 Kempton Park (ZA) Van Der Westhuyzen, Christiaan, Wynand Brackenhurst Alberton 0001 (ZA) Rousseau, Amanda, Loiuse Bedford Gardents 2007 (ZA) Parkinson, Christopher, John Thornhill 0001 (ZA)

(72) Inventors: KENYON, Colin, Peter 2188 Randburg (ZA) OLDFIELD, Lyndon, Carey 1618 Kempton Park (ZA) VAN DER WESTHUYZEN, Christiaan, Wynand 0001 Alberton (ZA) ROUSSEAU, Amanda, Louise 2007 Bedford Gardens (ZA) PARKINSON, Christopher, John 0001 Thornhill (ZA) (74) Representative: Waldren, Robin Michael  Marks & Clerk 90 Long Acre London WC2E 9RA London WC2E 9RA (GB)