(19)

(11)

EP 2 010 476 A2

(12)

(88) Date of publication A3: 24.07.2008 (43) Date of publication: 07.01.2009 Bulletin 2009/02 (21) Application number: 07755433.5 (22) Date of filing: 13.04.2007

(51) International Patent Classification (IPC):  C07C 211/00(2006.01) A61K 31/24(2006.01) (86) International application number: PCT/US2007/009160 (87) International publication number: WO 2007/120839 (25.10.2007 Gazette 2007/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 13.04.2006 US 744792 P (71) Applicant: Wake Forest University Health Sciences Winston-Salem, North Carolina 27101 (US)	(72) Inventor: KING, S. Bruce Walnut Cove, North Carolina 27052-7299 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)