(19)
(11) EP 2 010 676 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
20.02.2013 Bulletin 2013/08

(45) Mention of the grant of the patent:
09.01.2013 Bulletin 2013/02

(21) Application number: 07748437.6

(22) Date of filing: 26.04.2007
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
(86) International application number:
PCT/SE2007/050276
(87) International publication number:
WO 2007/126377 (08.11.2007 Gazette 2007/45)

(54)

METHOD AND KIT FOR MOLECULAR CHROMOSOMAL QUANTIFICATION

VERFAHREN UND KIT ZUR MOLEKULAREN CHROMOSOMENQUANTIFIZIERUNG

PROCEDE ET KIT POUR QUANTIFICATION MOLECULAIRE DE CHROMOSOMES

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

(30) Priority: 27.04.2006 US 795159 P

(43) Date of publication of application:
07.01.2009 Bulletin 2009/02

(73) Proprietor: Vytal Diagnostics AB
126 53 Hägersten (SE)

(72) Inventors:
  • HAUZENBERGER, Dan
    132 35 Saltsjö-Boo (SE)
  • KLANGBY, Ulf
    192 76 Sollentuna (SE)
  • HEDRUM, Anders
    138 35 Älta (SE)

(74) Representative: Berg, Anna Margareta 
Bergenstråhle & Lindvall AB P.O. Box 17704
118 93 Stockholm
118 93 Stockholm (SE)


(56) References cited: : 
WO-A2-02/068685
 US-A1- 2003 054 386
   
  • HULTEN M A ET AL.: "Rapid and simple prenatal diagnosis of common chromosome disorders: advantages and disadvantages of the molecular methods FISH and QF-PCR" REPRODUCTION, vol. 126, 2003, pages 279-297, XP002559856
  • CIRIGLIANO V ET AL.: "RAPID PRENATAL DIAGNOSIS OF COMMON CHROMSOME ANEUPLOIDIES BY QF-PCR. ASSESSMENT ON 18000 CONSECUTIVE CLINICAL SAMPLES" MOLECULAR HUMAN REPRODUCTION, vol. 10, 2004, pages 839-846, XP002559857
  • White H: "ChromoQuantTM (version 1) in vitro diagnostic test kit for analysis of common chromosomal disorders" National Genetics Reference Laboratory (Wessex) September 2005 (2005-09), XP002559858 Retrieved from the Internet: URL:http://www.ngrl.co.uk/Wessex/downloads /pdf/CQ1.pdf> [retrieved on 2009-12-09]
  • CIRIGLIANO V ET AL: "X CHROMOSOME DOSAGE BY QUANTITATIVE FLUORESCENT PCR AND RAPID PRENATAL DIAGNOSIS OF SEX CHROMOSOME ANEUPLOIDIES" MOLECULAR HUMAN REPRODUCTION, OXFORD UNIVERSITY PRESS, GB - BE, vol. 8, no. 11, 1 November 2002 (2002-11-01), pages 1042-1045, XP009019721 ISSN: 1360-9947
  • DONAGHUE C ET AL: "DEVELOPMENT AND TARGETED APPLICATION OF A RAPID QF-PCR TEST FOR SEX CHROMOSOME IMBALANCE" PRENATAL DIAGNOSIS, CHICHESTER, SUSSEX, GB, vol. 23, no. 3, 3 February 2003 (2003-02-03), pages 201-210, XP009019715 ISSN: 0197-3851
  • NICOLINI U ET AL.: "The introduction of QF-PCR in prenatal diagnosis of fetal aneuploidies: time for reconsideration" HUMAN REPRODUCTION UPDATE, vol. 10, 2004, pages 541-548, XP002559859
  • CIRIGLIANO V ET AL.: "Rapid prenatal diagnosis by QF-PCR: Evaluation of 30,000 consecutive clinical samples and future applications" ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1075, September 2006 (2006-09), pages 288-298, XP002559860
  • EYCHENE A. ET AL.: 'Chromosomal assignment of two human B-raf (Rmil) proto-oncogene loci: B-raf-1 encoding the p94(Braf/Rmil) and B-raf-2, a processed pseudogene' ONCOGENE vol. 7, 1992, pages 1657 - 1660, XP003015783
  • LEE H.H. ET AL.: 'Rapid detection of trisomy 21 by homologous gene quantitative PCR (HGQ-PCR)' HUM. GENET. vol. 99, 1997, pages 364 - 367, XP003015784
  • CIRIGLIANO V. ET AL.: 'Clinical application of multiplex quantitative fluorescent polymerase chain reaction (QF-PCR) for the rapid prenatal detection of common chromosome aneuploidies' MOLECULAR HUMAN REPRODUCTION vol. 7, no. 10, 2001, pages 1001 - 1006, XP003015785
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).