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EP 2 012 824 A2

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(88) Date of publication A3: 02.10.2008 (43) Date of publication: 14.01.2009 Bulletin 2009/03 (21) Application number: 07755413.7 (22) Date of filing: 10.04.2007

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C07K 16/24(2006.01) C07K 16/18(2006.01) C07K 16/00(2006.01) (86) International application number: PCT/US2007/009131 (87) International publication number: WO 2007/120823 (25.10.2007 Gazette 2007/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 10.04.2006 US 790909 P 30.05.2006 US 809770 P 20.06.2006 US 815489 P 29.06.2006 US 817891 P 25.08.2006 US 840122 P 02.02.2007 US 899262 P 02.04.2007 US 909683 P (71) Applicant: Abbott Biotechnology Ltd. HM 11 Hamilton (BM)

(72) Inventors: WILLIAN, Mary, Kaye Lake Forest, IL 60045 (US) OKUN, Martin, M. Wilmette, IL 60091-2119 (US) HOFFMAN, Rebecca, S. Wilmette, IL 60091 (US) GU, Yihua Vernon Hills, IL 60061 (US) Camez, Anne 68723 Schwetzingen (DE) MELILLI Lisa E. Norwalk, CT 06851-5421 (US) GORDON, Kenneth B. Stokie, IL 60077 (US) (74) Representative: Modiano, Micaela Nadia et al Modiano Josif Pisanty & Staub Ltd Thierschstrasse 11 80538 München 80538 München (DE)