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(11)

EP 2 013 197 A1

(12)

(43) Date of publication: 14.01.2009 Bulletin 2009/03 (21) Application number: 07716036.4 (22) Date of filing: 06.03.2007

(51) International Patent Classification (IPC):  C07D 401/12(2006.01) A61K 31/428(2006.01) A61K 31/454(2006.01) A61K 31/4709(2006.01) A61P 11/06(2006.01) C07C 211/36(2006.01) C07D 215/26(2006.01) A61K 31/137(2006.01) A61K 31/445(2006.01) A61K 31/4704(2006.01) A61P 11/00(2006.01) A61P 11/08(2006.01) C07D 211/26(2006.01) C07D 417/12(2006.01) (86) International application number: PCT/SE2007/000217 (87) International publication number: WO 2007/102771 (13.09.2007 Gazette 2007/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 08.03.2006 US 780251 P 05.04.2006 US 789516 P 14.07.2006 US 831091 P (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)

(72) Inventors: ALCARAZ, Lilian Loughborough Leicestershire LE11 5RH (GB) BAILEY, Andrew Loughborough Leicestershire LE11 5RH (GB) COX, Rhona Loughborough Leicestershire LE11 5RH (GB) MEGHANI, Premji Loughborough Leicestershire LE11 5RH (GB) PAIRAUDEAU, Garry Loughborough Leicestershire LE11 5RH (GB) STOCKS, Michael Loughborough Leicestershire LE11 5RH (GB) (74) Representative: Summersell, Richard John  AstraZeneca AB, Global Intellectual Property 151 85 Södertälje 151 85 Södertälje (SE)