(19)

(11)

EP 2 015 776 A1

(12)

(43) Date of publication: 21.01.2009 Bulletin 2009/04 (21) Application number: 07761070.7 (22) Date of filing: 20.04.2007

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C07K 16/26(2006.01) C07K 14/605(2006.01) (86) International application number: PCT/US2007/067152 (87) International publication number: WO 2007/124463 (01.11.2007 Gazette 2007/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 20.04.2006 US 793690 P (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)	(72) Inventors: SHEN, Wenyan Palo Alto, CA 94303 (US) GRAHAM, Kevin Thousand Oaks, CA 91362 (US) WINTERS, Katherine, Ann Thousand Oaks, CA 91360 (US) VENIANT-ELLISON, Murielle Thousand Oaks, CA 91360 (US) BOONE, Thomas, Charles Newbury Park, CA 91320 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Leopoldstrasse 4 80802 München 80802 München (DE)